This film focuses on two recurring characters from the movies of director Kevin Smith. Jay (Jason Mews) and Silent Bob (Smith) are a pair of New Jersey slackers who have been used as the templates for a pair of popular comic book heroes, Bluntman and Chronic. When they hear that their comic book alter egos are going to be turned into a major motion picture without their consent, Jay and Silent Bob head for Hollywood to sabotage the production. On their journey, they encounter various characters including an ape, a nun (Carrie Fisher), the cast of Scooby-Doo, a Charlie's Angels-style band of diamond thieves, and an unhinged wildlife ranger (Will Ferrell). Smith packs the movie with characters from his other films: Alyssa Jones (Joey Lauren Adams), Brian O'Halloran as Dante Hicks, Jason Lee as Banky Edwards, Alanis Morissette as God, and actors Ben Affleck and Matt Damon playing dual roles as themselves and two other familiar characters. Jay and Silent Bob Strike Back also co-stars a who’s who of Hollywood in various roles, including Shannen Doherty, Jason Biggs, James Van Der Beek, Shannon Elizabeth, Tracy Morgan, Judd Nelson, Chris Rock, and George Carlin, among others.